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    kevin2006's Avatar
    kevin2006 Posts: 78, Reputation: 1
    Junior Member
     
    #1

    Oct 27, 2007, 10:14 PM
    What intermediates accumulate in PK-deficiency?
    Does anyone know the 3 intermediates that accumulate in PK-deficiency (pyruvate kinase deficiency)?
    templelane's Avatar
    templelane Posts: 1,177, Reputation: 227
    Ultra Member
     
    #2

    Oct 28, 2007, 04:17 AM
    How to answer this question.
    1) work out what reaction the enzyme is involved in (glycolysis)
    2) Work out which specific reaction it does
    3) find a diagram/ flow chart of glycolysis
    4) draw on where PK works
    5) Look at upstream form the reaction, what reactions can take place but cannot proceed down the glycolysis pathway because PK is down?

    For example the Y gene is knocked out
    top line = reactions
    bottom line = enzymes

    A ----> B -------> C ---------->D
    __ X_______Y________Z

    This means you make a lot of B but it can't be converted into C
    So you will accumulate B and A
    kevin2006's Avatar
    kevin2006 Posts: 78, Reputation: 1
    Junior Member
     
    #3

    Nov 7, 2007, 09:20 PM
    Thanks man

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