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-   -   What intermediates accumulate in PK-deficiency? (https://www.askmehelpdesk.com/showthread.php?t=145730)

  • Oct 27, 2007, 10:14 PM
    kevin2006
    What intermediates accumulate in PK-deficiency?
    Does anyone know the 3 intermediates that accumulate in PK-deficiency (pyruvate kinase deficiency)?
  • Oct 28, 2007, 04:17 AM
    templelane
    How to answer this question.
    1) work out what reaction the enzyme is involved in (glycolysis)
    2) Work out which specific reaction it does
    3) find a diagram/ flow chart of glycolysis
    4) draw on where PK works
    5) Look at upstream form the reaction, what reactions can take place but cannot proceed down the glycolysis pathway because PK is down?

    For example the Y gene is knocked out
    top line = reactions
    bottom line = enzymes

    A ----> B -------> C ---------->D
    __ X_______Y________Z

    This means you make a lot of B but it can't be converted into C
    So you will accumulate B and A
  • Nov 7, 2007, 09:20 PM
    kevin2006
    Thanks man

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