My sister was diagnosed with stage I've colon cancer 2 years ago. She has had surgery, 2 rounds of chemotherapy and radiation treatment. She was told recently that there is nothing else the doctors can do other than pain management. The cancer has spread to her brain, her lungs, her liver, vertebrae, and her hip... as of this week, her legs are swollen. Does this suggest organ dysfunction and that she may be close to dying? If yes, how close