I want to frame up a small reach-in closet in my bathroom (2x4's, drywall), but I have an obstacle: My ceramic tile floor covers cement board and a sub-floor with radiant heat/water-filled PEX.

The 5 foot length of closet will span one wall, with short sides. The back of this closet will be securely fastened to an existing wall and ceiling. However, can I secure the sill/floor 2 x4's with a strong adhesive? I don't want to risk nails of any size hitting the PEX.

Liquid nails

Or pl premium which gives you more of a chance to work with it ( 24hr. Dry time)

Razor, if that's the one that comes out of the tube blue on one side and gray on the other side I agree 100%. Liquid nails will work too. Open this but before you do guess how many product Liquid Nails makes. Make.Liquid Nails - ProductListing