Is it possible for the father to be blood type O and the mother to be blood type A and have a child with blood type B? If so, how?
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Is it possible for the father to be blood type O and the mother to be blood type A and have a child with blood type B? If so, how?
Yes, it is possible.
There is a rare blood type called hh (Bombay blood group) which prevent the expression of the A & B antigens. So a person who has the A and/or B alleles (genotype) will have the blood type O phenotype. See the Hh antigen system at Wikipedia (hh antigen system - Wikipedia, the free encyclopedia) for the details.
Possible…. But how frequently does this happen?
Well it depends. In Europeans it’s is very rare (one in a million), but more common in other places. In India (remember it’s the Bombay phenotype) it is 100X more common & on Reunion Island (Réunion - Wikipedia, the free encyclopedia) the frequency is one in a thousand.
The genetic details for the H/h blood group are a little more completed (two homologous, linked genes (FUT1 & FUT2) with different tissue specific gene expression patterns). Check out dbRBC - Blood Group Antigen Gene Mutation Database for the details.
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