Does anyone have any ideas of how to cut down on the smell that my Guinea pigs have? I change their fleece very often and spray the room with air freshener very often. Would a deodorize spray help?

First, they just smell. How often is often, every two or three days?

What do you use for bedding? Spot cleaning is important but cleaning/changing the bedding is more important since it's the urine that usually gives the smell you are referring to.
Don't spray the room, that may not be healthy for them.

Do you use pine shavings? I did and would clean out the corners where they'd usually pee/poo every day. My cage never smelled and the Guinea pigs smelled like shavings.

I use a mixture of pine and cedar shavings for my bunnies, and it's amazing. I do a spot clean every day, just the corner they pee or poo in. Once every two weeks I do an entire bedding change, wash out the entire cage and replace all the shavings. At one point I had 4 rabbits all in the house, and we never smelled them at all. No one coming to visit knew we had rabbits until they saw them.

Cage size is also important. Buy the biggest cage you can so they have more room and more places to mess.