I thought it was from Top Gun but just watched it again and this scene is not in there. It's 2 guys riding side by side on motorcycles and they pass the san onofre nuclear station on the 5 freeway in San Diego. The one guy looks at the other guy and points out the nuclear station because it looks like boobs. They both laugh. Please help, this is driving me crazy!

I don't know about the motorcycles, but the reactors were shown in the movie Naked Gun...
Naked Gun 1 everywhere I look - YouTube

There are two Top Gun parody movies called Hot Shots and Hot Shots: Part Deux. I know Charlie Sheen was on motorcycles in those films, maybe you're confusing that with that Naked Gun scene.

Good point ilnot1!