I have been on pravastatin 40 mgs.over 1 year now. My cholesterol has been normal since then.I am also on pristiq 100 mgs. About 5 years now. My question is I have muscle pain in my legs.only when I am sitting ,which is a lot since 2005. When I am walking around I feel no pain. I used to exercise a lot but since 2005 when Katrina hit I really gt depressed and just sat around a lot. Had no muscle pain then.some but not much. Since I started the ststins I have had muscle pain in my legs. As I said it is mostly when I sit.when I do walk my legs don't hurt.could this be caused by the statins or just the lack of inactivity.I am sure I have lost a lot of muscle mass. Depression seems to be better so I am asking my psychiatrist to start weaning me off. Thank you for readind my questions and hope to get a reply soon,jacqueline [email protected]