With fail in 1 subject does matter in F1 visa interview?If counselor ask me what should I tell?

It all depends on what you want to do financially. If you failed one subject then will you not have to do that over again to complete your education?

You can have your visa extended, but may have to go back to your home country to do that.

There is no sense in lying about it, just ask the counsellor's advice on what can be done to complete with a renewal.