How Much Interest Will $500,000.00 Earn In 1 Year?

Really depends on where and how you invest it.
I'll give you a 50% return in 1 year ;)

That depends on the interest rate at which you invest, the term of the investment (the length of time you invest the money), whether the interest is compounded and the period (daily, weekly, etc.) of compounding, if there are periodic withdrawals or addition of principal, whether the year is measured on 360 or 365 days, etc. There are lots of complicating factors.

In a simple case like yours seems to be, if you invest $500,000 at 6% for one year simple interest, let us say, you'll earn $30,000. Compounding will increase the amount you earn.