I have a Richmond Two dollar bill dated February 17, 1864 and I think the number on it is04505. It also has a letter E on the both corners. Can you tell me is it worth anything?

Cofederare money lost its value when the south lost the war. Sorry, but not even worth the paper it is printed on

There are many collectors who will pay good money for authentic bills in good condition. There are a great number of forgeries out there too. You need to have it appraised. A List Of Known Facsimile Confederate Notes