I have had my puppy from day 1 I have his mom and brother, but he has not eat for 3 days he is throwing up and diarrhea for 2 days and won't drink. I think it might have been something he eat he is 12 weeks and mom and brother are good

Please get this dog to a vet asap. He sounds very sick! He will not live much longer without food and water. If he has parvo, his sibling and maybe his mother are also in danger of getting sick and dying.

There is only 1 vet in my small town and they are not open till Monday

My guess is the pup will be dead by then, or close to it. And the other pup is in very much danger. Do you have Gatorade or Pedialyte? The sick pup must be hydrated (given liquids). Use an eyedropper to give him some frequently. Is there a vet emergency number to call?

Yes, keep the puppy away from the other dogs, and don't let them around the area where this dog is. Yes he may not last till Monday, so he needs to get to a vet

Another precaution to guard against possible contamination of sick pup would be to use Clorox Bleach (use as directed on container for disinfecting) and disinfect all areas that other dogs could come in contact with. Spray bottle works great.

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Originally Posted by laurcia

I have had my puppy from day 1 i have his mom and brother, but he has not eat for 3 days he is throwing up and diarrhea for 2 days and won't drink. I think it might of been something he eat he is 12 weeks and mom and brother are good

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Is pup any better? Have you been able to give him any fluids or nutrition----I placed a call to my vet----but no answer yet------I wish pup well. FFrank ---P.S. What kind of pup is this----large or small breed?

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Originally Posted by laurcia

I have had my puppy from day 1 i have his mom and brother, but he has not eat for 3 days he is throwing up and diarrhea for 2 days and won't drink. I think it might of been something he eat he is 12 weeks and mom and brother are good

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What did he eat? These are symptoms of everything from parvo to a stomach upset to poisoning.

He needs to see a Vet - in the meantime, yes, keep him hydrated.

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Originally Posted by Frank Mangrum

Another precaution to guard against possible contamination of sick pup would be to use Clorox Bleach (use as directed on container) and disinfect all areas that other dogs could come in contact with. Spray bottle works great.

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This is dangerous advice if the other dogs are in the vicinity - the advice is to mix, WIPE DOWN the surfaces, dry - to be on the safe side rinse and then dry.

He is the same keeping down a little of water. He is a large breed dog

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Originally Posted by laurcia

He is the same keeping down a little of water. He is a large breed dog

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He had a toy duck and some of the pieces are gone ( plastic) I throw it away when I found a bite out it

Try giving him gatorade or pedialyte to keep hydrated and attempt to balance electrolytes.
The cleaning should be done with 1/32 solution of bleach and water. One part bleach to 32 equal parts water, you do need to keep them separated if this parvo. You should also get rid of any bedding, toys, soft items that you can't clean.
You can bleach food and water bowls or throw them out and get new, up to you.
Is the diarrhea foul smelling and bloody looking?

Is the other pup fine at this point?

Eating/drinking/ normal stools and activity?

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Originally Posted by LadySam

Eating/drinking/ normal stools and activity?

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Yes the other puppy is fine

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Originally Posted by LadySam

Try giving him gatorade or pedialyte to keep hydrated and attempt to balance electrolytes.
The cleaning should be done with 1/32 solution of bleach and water. One part bleach to 32 equal parts water, you do need to keep them separated in the event that this parvo. You should also get rid of any bedding, toys, soft items that you can't clean.
you can bleach food and water bowls or throw them out and get new, up to you.
is the diarrhea foul smelling and bloody looking?

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its not bloody but foul smelling yes

If you are missing toy parts then it is possible that he has eaten them and this is causing his troubles. That still doesn't count out parvo if exposure time for the other pup was different.
This still is not to be taken lightly if he has an obstruction he could still be is serious trouble when you are able to get him to the vet.
Have you checked to see if there is an emergency facility in your area?
It would be a little more expensive. But your pup may not be able to wait.

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Originally Posted by LadySam

If you are missing toy parts then it is possible that he has eaten them and this is causing his troubles. That still doesn't count out parvo if exposure time for the other pup was different.
This still is not to be taken lightly if he has an obstruction he could still be is serious trouble when you are able to get him to the vet.
have you checked to see if there is an emergency facility in your area?
It would be a little more expensive. but your pup may not be able to wait.

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there is no emergency vets near me they are all about an hour away

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Originally Posted by laurcia

He is the same keeping down a little of water. He is a large breed dog

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Sorry still no call from my vet---Seems I am in same boat as you---NO VET CARE ON WEEKENDS---Since pup is a larger breed you have a better chance to see vet Monday. Keep pup as hydrated as possible and give food as allowed. We will hang in there till Monday if need be---- I will try my vet again----Keep me informed----Best wishes---fFrank--- P.S. Please see one hour away vet if pup gets worse. It may be very well in pups best interest if you see vet A.S.A.P.

Well none of us can diagnose over the internet, but from the sounds of things it could be a number of things.
Parasites, parvo, obstruction, dietary indiscretion.
So a few more questions if you don't mind, mainly to give you something to think about.
Has he been dewormed?
Has he gotten into any trash or different food than he is used to?
Has he been around other unvaccinated pups or dogs or to the dog park or any other public place where dogs are?
What color is the poop? Normal color or dark?
Is he only throwing up after eating or is he trying even when he hasn't eaten or drank anything?
Now get the number to the emergency clinic and give them a call, give the answers to these questions and have them advise you further. They can't diagnose over the phone but with much information they will be able to guide you.
Make sure to tell them about the toy.
A phone call will cost you nothing and may be helpful to you.
Ask about prices in case you get in a bind and have to take him in.
I know it's a long drive but you may have little choice if you have a way to get him there.
Give them a call and come back and tell us how it goes.