My buick lesabre turn off after 3 or 5 min aprox running or not, I change the crank sensor, then change cam sensor, also change coils and ignition module but problem persists, what else can I do ?

When the car shuts off, are you losing spark or are you losing fuel pressure?

. Check, or replace, the ignition switch for wear or pitting.

. Check for codes. Do you have any reason to suspect the PCM is failing?

Do you have a security system that may be failing?

Looses spark, the car shut off inmediatelly like if turning off switch, it doesn't shows fuel failure before shut off, and turn on again withouy any problem, I also repair crank sensor wire harness because it looks like burned in some places but only wire insulation not plastic housing

Another thing, the codes shows cruise control failure

What concerns me is that there was any wiring damaged. Do you know what may have caused the crank sensor wiring to look burned?
And what was the actual code (that showed the Cruise Control failure)?
When I see a stall that will immediately restart, I almost always suspect either an Engine Control Module (ECM) fault (the module overheats and shuts off) or possibly a fuel delivery issue.
I have also seen where the gas cap was the fault: after the vehicle has been driven, the fuel tank cannot draw outside air in through the fuel cap as designed and the car starves for fuel.
Your car may need more diagnosis to pin-point the actual fault.