Okay well we have been best friends since grade 3 and we have had some rough times with our relationship but suddenly she is mad at me. And the worst part is is that I didn't even do anything wrong to her. And even if I did, she won't tell me what it was. What should I do?

The best thing to do is don't ambush her with questions, maybe she's just in an irritated stage. Have you noticed if she's been irritable to everyone or just you? Maybe Try making her cookies? (: That's always cute. Or apologize even though you don't know what you did. Just understand and acknowledge that you know she's mad at you and you're truly sorry for whatever you may have done. Best friends don't just fall apart for some reason, so you guys should patch things up before it's too late. <3 I'm sorry if I didn't help. Best of luck!

I think you should wait a little... And then ask her what you did or said that made her angry. If she really is your friend, she'll tell you.