I don't mean F11 - fullscreen, I just want it to open as large as it can. I have tried to open a window, resize it to large then close it and reopen. Setting muse not be saved or something. Tried Tweak UI but could not find an answer.

Dave

Try this:

Right click the shortcut icon for IE next to the Start button, choose Properties, change it from 'normal' to 'maximized'. Now open it.
Now right click any link on the page, choose Open In New Window... don't maximize it... instead, use the mouse to resize it to what you want it to be.
Now close the FIRST window you opened, and then close the new one you just resized.

Reopen IE from the shortcut icon again, and all windows from now on will be the size you chose and created.

There is a utility that maximizes all newly open windows, are you interested in that?

Here's the link (the program got better since the last time I saw it):
Keep Internet Explorer Maximized - AutoSizer