Here's the deal... last August I had 2 puppies that got very sick, diarreah, vomiting. Ultimately, I lost one, save one with pedialyte and immodium. Now, I have 2 puppies, same thing. Same fathere, different mother, although the mothers are sisters. The puppies, all 4, had never been outside a day in their life. The first 2 had been wormed, the second set had had their 1st round of shots. Its like de ja vu. I don't want to, don't think I can handle losing these furry babies... please help

You need to take them to the vet. People can carry the parvo virus in on their shoes and clothing. Parvo can easily be prevented with vaccine. Most times Pups who come in contact with the disease need IV fluids. Parvo viruses can also live in bedding, soil, water and food dishes, basically any favorable environment for up to 5 years! Please seek help from your vet!

And, please, get your dog spayed.

Are you a breeder? I notice the "mothers" are sisters and you also own the "father" of both litters.

More information is needed. How old are they now? When did they have the deworm medicine? Did the diarrhea & vomiting start after the de worm medicine?
I was a Vet Tech for 12 years.