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-   -   A linear epitope (https://www.askmehelpdesk.com/showthread.php?t=438827)

  • Jan 24, 2010, 09:48 PM
    Gernald
    A linear epitope
    Can anyone tell me what exactly a linear epitope is and what it does? I have a short description in a text book but it's not very descriptive and the jargon is a bit hard to understand.
  • Jan 26, 2010, 09:46 PM
    jem02081

    An epitope is a region of a protein which an antibody binds to. A protein is a linear chain that folds up in a complex manner. If the antibody binds to a continuous amino acid sequence of the protein it is termed a linear epitope since the protein is linear amino acid chain. An antibody could also recognizes (binds to) a number of amino acids which are nearby in the protein 3D conformation, but which are not continuous, In this case it is termed a conformational epitope.
  • Jan 26, 2010, 10:54 PM
    Gernald

    Thanks!

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