This question might be more appropriate in another section, but I thought I would start here since the experts might use these nailers.

I'm looking at air powered finish nailers, one with a straight frame and one, an angle finish nailer. Besides the obvious difference, is there an ADVANTAGE of one design over the other?

I personally like the angled nailer best helps me get into tighter places. I own two a 16 gauge straight and a 15 gauge angled. Both are great tools but again if I had to pick the angled nailer would win. GOOD LUCK ,AC

Angled finish nailers are far superior in my experience as a finish carpenter. I own both a 15 ga. Angled nailer and a 16 ga 16 nailer. I rarely use the 16 ga, mostly because the angled gun will hold longer (2.5in) nails. Great for installing doors and larger moudings. The straight gun does give you the option of an intermediate sized nail between a brad gun and the angled nailer though, which is nice... If you are doing a wide variety of carpentry, buy all three!