My best friend of ten years has decided to start trying many different types of pills lately, anything from loratab to vicodin. I have tried telling her to stay away from these things because this is how my brother who is now into things that are much harder drugs started. She doesn't want to listen to me because I myself used to be into vicodin, but I stopped and she seems to just be getting worse. At this point she is trying to get basically anything she can get her hands on. The people she works with always seem to have a supply of something. I really don't want to lose her as a friend, but I was just curious if there is any route I can take to help her, while not completely getting her pissed off at me.

There really isn't anything you can say or do. People make up their mind to do something and they get hard headed and thing they will be the one that doesn't get hooked. Then they spend years in denial.
You can talk to her as a friend and show you are concerned but don't get your hopes up.

Her main problem is that she is a big time follower, she seems to think people will like her better if she does what they are doing.

Yeah many people are like that.

I think that it is important to tell your friend how much you care. Important to remind her of all of the good things she has going for her and about her. Research and share with her the issues associated with being addicted to the meds she is currently tampering with and continue to be a friend. Which sometimes means doing things that may upset the person but that you as a friend can do to show how much you care. It's hard to sit back and watch someone destroy themselves and important as the friend to try your best to save them. Best wishes

What may help is staging an intervention.
Let her know that not only do you care, but there are many people in her life that care.
That you won't support her ruining her life with drugs.

Just as N0help stated, addiction is a very difficult disease for some people.
Everyone's personal 'rock bottom' is different.
It's ultimately going to be up to her to discover the dangerous path she is on.
Many don't ever wake up once they are addicted.

Talk to her with your whole heart, but mentally prepare yourself to be let down.
My mother has been an addict for the last fifteen years, from everything that started with Tylenol 3, went to alcohol, liquid Nubaine, coke, crack, Vicotin. It's a long path and eventually you have to put aside your feelings for someone who stops caring about themselves, if it gets to that point.

Thanks for all of your help, I think I'm going to have to try and sit her down to talk. I don't know how it will go, but I guess it's the best thing that I can do.

Beings I know who you are. You already know my feelings about this situation. You need to sit her down and talk with her. I realize that she will be rebellious only because she knows you used to do the same things, but you have to show her, tell her that things are much better clean. Be there as a friend, be there as someone who loves her and cares for her but like someone above said be prepared to lose her. Only she can fix what she's done, you have to be willing to tell her that you won't watch her as she destroys her very being and be prepared to walk away!

Rick