Hi my name is Ramona and me and my husband have guardianship of my niece and nephew and we now want to adopt them so what should we do? Where do we start?

Depends on what state you are in, I'm sure. Is your guardianship legal through the courts? If so, you might be able to go in a file for temporary/permanent custody, which I believe is slightly different than guardianship. Your best bet would be to talk to a family law attorney, and/or court facilitator.