I've 200 Win XP PC where more than 15 application run at a time but suddenly all open application closes showing abnormal program termination in IE v6.Is there any solution.

Have you tried resettin your IE ? This will clear for example your browser history & basically resets all extensions, just try that I let us know ! Reset your IE

Do you have all you Microsoft updates?

As mentioned, reset defaults
-tools, interent options, advanced, reset defaults