I see a lot of Help Desk and\or Project Management software packages on the market; however, does anyone have any experience with any packages that are all-inclusive of both of these disciplines?

Our company uses Microsoft CRM. Fine for Help Desk and Customer Contact Management, I believe they have Project Management Add-ons that would integrate the whole thing.

Expensive though. Very expensive.

Not sure about the best collaboration but you should consider two good Help Desk Software available.

1. Helpdesk Pilot
2. OS Ticket

I will suggest Helpdesk Pilot. Its easier to setup and use. You also get free installation service