Can a improper axle replacment on a CRV cause a transmssion to fail. I had mine replaced and shortly after the transmission failed. Transmission people said the end of axle was chewed up where clip had fallen off causing to move in and out. I was also told that after axle market sometimes uses wrong clip size and this could cause transmission to fail.
Would appreciate any feedback on this.

Unfortunate development. Hopefully, others can learn from your experience. The inboard end of the driveshaft is supposed to be inserted into the differential, until the set ring locks in the groove. Honda recommends, "Always use a new set ring whenever the driveshaft is being installed." Honda cautions, "Make sure the inboard joint bottoms into the differential, and that the set ring locks into the groove of the side gear."

I would check to see if the replacement axle was adjusted to the correct length and if the spindle nut was properly torqued and staked. Many repair shops rarely use torque wrenches anymore--everything is done with air. This is another reason why I prefer to do the work myself. If you can't do the work yourself, my experience has been that you are best to get the vehicle serviced at the dealer or at a shop that specializes in your vehicle.