I smoke cigarettes, and have occasionally partaken in the 'wacky tabacky' and have briefly experemented with other sorts of drugs. And none of them effect me in the same way as they do others. It either takes more of the substance to work or it just has no effect. The same is true for caffine an other such things. Is there an explination for this?

You might just have ahigh tolerance I have done most drugs like E's,coke,ketamine,speed,acid,and smoked pot or hash theirs many names for it not going to list them all,but I had high tolerance aswel,I'm the same with painkillers I had ajaw infection because of abad tooth and I used 130 painkillers in aweek and ahalf and the next painkiller up from the ones I was on was morphine but can't be takiing that when I've got 2kids to look after,everybody is different