I have a 4week onl cockopoo that will not eat out of the bottle or from the mother what can I do ?

Better check with a vet. I am not sure what the problem could be. I am sure the books on breeding discuss that and many other problems. If you haven't read any of them, I question if you should be breeding dogs. There is no end of misery due to poorly informed people breeding more dogs than we can found homes for.

There was another question here tonight from somebody with a 5 week old puppy. No breeder that knew what they were doing would have sold a 5 week old.