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-   -   Pregnancy and yeast infection (https://www.askmehelpdesk.com/showthread.php?t=101623)

  • Jun 15, 2007, 08:17 PM
    sariev
    Pregnancy and yeast infection
    I had a pap smear at my last dr.'s appointment and they called to say I have a yeast infection although I have no symptoms. I am currently 11 weeks pregnant and they prescribed gynazole 1 but I am hesitant to use it. Does anyone know if there are risks of using it while pregnant? Also, does anyone know if it is OK to not treat a yeast infection, particularly if you have no noticeable symptoms or will that hurt the baby? Thanks for any info!
  • Jun 15, 2007, 08:53 PM
    alkalineangel
    Pregnancy:
    Pregnancy Category C.
    In pregnant rats administered 6 mg/kg/day of butoconazole nitrate intravaginally during the
    Period of organogenesis, there was an increase in resorption rate and decrease in litter size;
    However, no teratogenicity was noted. This dose represents a 130- to 353-fold margin of safety
    Based on serum levels achieved in rats following intravaginal administration compared to the
    Serum levels achieved in humans following intravaginal administration of the recommended
    Therapeutic dose of butoconazole nitrate.
    Butoconazole nitrate has no apparent adverse effect when administered orally to pregnant rats
    Throughout organogenesis at dose levels up to 50 mg/kg/day (5 times the human dose based on
    Mg/M2). Daily oral doses of 100, 300 or 750 mg/kg/day (10, 30 or 75 times the human dosebased on mg/M2 respectively) resulted in fetal malformations (abdominal wall defects, cleft palate), but maternal stress was also evident at these higher dose levels. There were, however, no adverse effects on litters of rabbits who received butoconazole nitrate orally, even at maternally stressful dose levels (e.g. 150 mg/kg, 24 times the human dose based on mg/M2). Butoconazole nitrate, like other azole anti-fungal agents, causes dystocia in rats when treatment is extended through parturition. However, this effect was not apparent in rabbits treated with as much as 100 mg/kg/day orally (16 times the human dose based on mg/M2). There are, however, no adequate and well-controlled studies in pregnant women. Gynazole·1® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
    Source: FDA

    Your doctor should have given you a prescription or recommend a specific over-the-counter antifungal vaginal cream or suppository that's safe during pregnancy. You should not take oral anti fungal prescriptions

    A yeast infection won't hurt your developing baby, but If you still have the infectionat the time of labor, the baby could contract it on his way out and develp thrush (yeast in the mouth)

    DId you go to your OB/midwife or was this a General Doctor?

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