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my thoughts: Paul was a human being led by the Spirit. However, he was NOT the only human being led by the Spirit. He was warned by other Christians what would happen if he went. I can understand his heart. He loved his Jewish people, he KNEW it was the Lord's heart for all to be saved...HE was NOT called to minister to the Jews. Yeah, He GOOFED. God love him.
I'm inclined to agree with T here. "In the Spirit" in Acts 19:21 could just as easily be "in his spirit" rather than the Holy Spirit. The NIV seems to think so, it reads "he decided to go to Jerusalem." Gonna have to dig into that phrase a bit more, but it sure sounds like he made a decision, the Holy Spirit warned him of the consequences, and he said "challenge accepted."