[vibhorg2006]

I am 63 years of age and suffering of loss of haemoglobin.blood transfusion done .After blood transfusion haemoglobin reaches to normal value but again decreases abnormally within weeks time.I am a diabetic patient.Blood sugar also increases.Right now suffering from jaundice also.Pls suggest if jaundice results in loss of haemoglobin.Doctors done a lot of tests still find no reasons for loss of haemoglobin continuously.Pls suggest for the loss of haemoglobin.After blood transfusion haemoglobin increases and reaches to 14 but in weeks time it drastically decreased to 6,then again to do blood transfusion.What is this anemia and concrete solution for it.

[bkdaniels]

The best advice for treatment is for you to remain conservative. Avoid additional transfusion unless your life is otherwise threatened.

Loss of haemoglobin is common after massive transfusion although, it is not used as the only indicator of Complication of donor blood. Your Physician will consider other factors and determine if you will need regular transfusions.

However, this subject is in constant debate. Many patients are able to tolerate lower level of hemoglobin than was previously believed.

Scientists are now believing Transfusing to normal haemoglobin levels will not improve the outcome of mortality and other clinically important outcomes i.e. organ failure. Other adverse effects of RBC transfusions, such as pulmonary oedema from volume overload, immune suppression resulting in increased risk of infection, and microcirculatory injury from poorly deformable RBCs must be investigated.

The main goal of theraphy is therefore, to make more efficient use of RBCs and save blood overall. This mode of treatment helps to prevent other major nonimmune transfusion reactions due to circulatory overload, massive transfusion, or transmmission of an infectious agent.

Hope this answers your question!

REFERENCE(S)

1. Gonzalo Alvarez, Paul C Hébert, and Sharyn Szick, 2001. Debate: Transfusing to normal haemoglobin levels will not improve outcome

2. Merck Manual Professional, 2006. Autoimmune Hemolytic Anemia: Anemias Caused by Hemolysis: Merck Manual Professional



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(or 'transfusion trigger') may result in unnecessary administration of blood products, with their concommittant risks.