[jasmynn]

hey miss c i am also using hq20% and it works great thanks for your post.


your fellow whitening buddy

Where did you get your HQ20%

[PinkMoscato]

Where did you get your HQ20%

Please message me as well.. Did you MIX or buy your HQ 10%?

[wannabwhite]

I tried to mix the hydroquinone powder into a 4% hydroquinone cream that I already had and it didn't dissolve. I had it in hot water for like 30 minutes, and the crystals still formed after like 3 days... I tried again, but this time for like 15 minutes in hot water and instead of the hydroquinone cream, I mixed it in a moisturizer. But the cream turned into a liquid form and stayed that way. I guess the whole mixing thing is not going to happen for me. Im stressed out to the point where I'm thinking about getting steroid based whitening creams... :(

[katvon]

You have to dissolve the powder in warmed proplye gycol (sp) then add to cream after its dissolved

[katvon]

Kligman's original forumula was indeed:

Hydroquinone powder 5%
Dexamethasone powder 0.1%
Tretinoin powder 0.1%
Hydrophilic ung qs ad 60gm

The reference is O.H. Mills and A.M. Kligman, J. Soc. Cosmet. Chem. 1978,
29, 147.
There are of course other variations. One pharmacist I know dissolves the HQ
Powder in propylene glycol prior to mixing in hydrocortisone powder,
Tretinoin powder, and then blending with Unibase cream.

I credit Kligman with all variations of the concept of hydroquinone,
Tretinioin, steroid creams. The exact method of preparation of what I was
Using with great success was combining in order

Water 3ml
Hydroquinone powder (Kodak) 5gm
Retin A 0.05% cream (DNS) 15gm
Lidex cream (DNS) 15gm
Eucerin cream (DNS) qs ad 50 gm

The HQ is dissolved in the water first, then the creams are combined, and
Finally all are mixed thourougly by hand. This makes 50gm of a very nice
Stable bleaching cream which emulsifies nicely. The fluocinonide content is
0.015% and use is carefully monitored by giving the patient 10gm jars at a
Time. I have never seen atrophy or steroid induced rosacea from use of this,
But it is a concern of course. The patient is instructed to apply at hs and
Use high SPF sunscreen every AM. The advantages are: 1) Patients love it, a
Prescription made just for them by the dermatologist, and they don't have to
Pay for it. NO prescription cost to the patient 2) minimal cost to the
Dermatologist since ingredients are free samples except for the HQ powder
Which is inexpensive 3) very individualized treatment with control of supply
By the dermatologist. The problem is that samples of Lidex cream (DNS) are
No longer available, and I have had problems with the emulsification of other
Steroid creams (they tend to separate in a few days). Horror of horrors, I
May actually have to buy ingredients?

All of this raises the question: how many dermatolgists and pharmacists are
Doing traditional compounding? What are favorite recipes for various things?
Is traditional compounding becoming a lost art?

Walter H. Wood, M.D.
--------------------

In our setting, we have tried from low potency: hydrocortisone to mid
Potency fluocinonide or betamethasone combination in our bleaching
Preparation. We find the combination hydroquinone + Tretinoin .05 +
Hydrocortisone to be the most effective in terms of effect and cost.
Hydrocortisone is cheaper in Manila. Lately we are trying to use desonide
Cream (DesOwen) to see if it is better than hydrocortisone.
In regards to separation in your Lidex E, how to you prepare your
Hydroquinone powder? Do you use propylene glycol to dissolve it? It might
Be the diluent that is reacting with the emollient base of Lidex E.



Jonathan Yu, MD
Skin & Cancer Foundation
Makati, Philippines
-------------------


Perhaps I should try propylene glycol instead of water. There does seem to
Be something unique about the emulsification of regular Lidex cream that
Made everything work. Mixing already optimized creams is definitely tricky.


Walter H. Wood, M.D.
--------------------


------------
AZELAIC ACID
------------


How about asking the company which makes azelaic acid for acne to supply some
To you on an investigative basis for depigmentation? Dr. Nazzaro-Poro in
Italy reported its use for depigmentation about 10 years ago. If Benoquin is
Unavailable, there might be a good market for azelaic acid as a substitute.

Yelva Lynfield, MD
------------------



In the literature at least, azeleic acid is about as effective as
Hydroquinone for melasma, therefore I have not considered it an effective
Substitute for the much more potent benoquin.

Mark Ling, M.D. Ph.D.
Emory University Department of Dermatology
Clinical Pharmacology Unit
Atlanta, GA
-----------



Azeleic acid will not depigment normal skin and only works well on areas
Where the pigment is active, i.e. melasma. Old post inflammatory pigment or
Deep dermal pigment isn't touched.However, melanex applied first,
Followed by azeleic acid, is better than melanex alone by quite a
Bit.

Haines ELy MD
-------------




-------
4.17.96

[katvon]

This might help

[portland]

I was reading this post, and I have some experience in creams preparation and a little of knowloegde in chemistry, So is think that is best to mix hydroquinone in propilenglicol previosly and then mix it in a cream. But you will neeed to have caution with several problems

1)hydroquinone will precipitate and separate from the cream within a few days so you will have to shake it strongly before every use.
2) hydroquinone exposed to the air oxides rapidly, and your mixture will last no more than a week (researching the duration of hydroquinone powder in 1L, it has a duration depending of the storage, in a full botle can keep it for longer than in a half bottle for example, and in galon can take longer in get oxidized . When this happen, it could get worst hyperpigmentation.(that's because you cannot take sun using HQ! Because it gets oxidized) So I recommend to prepare minimal volumes that you will use in no more than a week, and then re-prepare.

These are helpful securrity tips. Remember that HQ have severely potencial complications, so use it with responsibility and controlling every factors (oxidation of HQ, sun exposure, % tolerated and tested for your skin (never more than 10%) , interaction with other agents, I know that Hydrogen peroxide can react strongly with HQ resulting horrible burns, Remember that HQ is EXTREMELY DANGEROUS for skin type V and VI.