When they ask questions.
It is a good idea to start talking about their bodies and their "parts" when they are young, but not in a sexual way, just the basic "this is your vagina, this is your penis, pee pee comes out of there, it's your private place." stuff like that.
If you start talking when they are young you'll build the trust that you will need when they become teens. If they know that they can ask you anything and get a correct and accurate response, then they will continue coming to you with their questions. Let them dictate how much info to give and when to give it, there is not set age.
Good Luck.
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