I have a glacier bay kitchen faucet with a spray hose. If I do not attach the spray hose to the faucett will the water come out of the o ring connection on the faucett when the faucett is being used?

Yes. If you do not wish to use the spray, connect it and coil it up (tie it with a couple tie wraps) under the sink.

Good advice From Harold. You may also
Purchase a brass plug and disconnect the hose. You can fill the open hole on the sink with a soap dispenser. Good luck, Tom