I have a PC speaker sub woofer with a blown fuse. I was wondering can I replace it was a normal blow fuse?
It currently has a Lf.5al250vp fuse which to my understanding is Littlefuse - Time delay/slow blow 5a 250v non-lead?

Can I replace it with a normal blow 5a 250v fuse?

Take the time and find a slow blow... a regualr fuse (fast blow) is far more likely to blow without a good reason... and a larger one will provide no protection against damage.

Time delay fuses are for motors that pull LRA Locked Rotor Amps, several times normal for a millisecond unless your loads pull high starting amps you do not need time delays.