What makes a 11 week old puppy pee's on her safe at night when she sleeps...

I don't know what "she pees on her safe" means - are you saying she's urinating without waking up? Are you saying she can't wait until morning to go outside?

She pees on her safe? You put her in a safe? I don't understand what a safe is to you. Is it a crate, the couch, a rug, her fur? A safe is a container that you put precious documents or money into. It's air tight, and has a lock. It's no place for a dog.