I've had a fissure for probably a couple of decades now, but it's a recurrent one. That is it may heal and disappear for long periods, sometimes lasting to 6-8 months only to re-appear again, sometimes just for a few days, and once a few years - for a few weeks on end. I keep a relatively good healthy diet and normally a regular daily bowel movement, but sometimes slips occur and if your body is tired (like after bad sleep) even a healthy diet won't help the fissure from re-opening again. A few years ago my GP gave me a tube of isosorbide dinitrate, which I apply whenever I have a re-opening again (about 2 times a year). At times I think the fissure has at last healed only for it to re-open again. I have seriously considered surgery but at the same time would have course like to avoid it. At the same time I realize using the cream permanently can cause side effects and the body can develop tolerance for it rendering it a lot less effective. Has anyone had such a case of recurrent fissure and was able to heal it to a degree where it occurs not at all or very rarely (say once a few years, once a decade)?