I have 1 wired PC, 1 wireless PC, an Ipod touch, and nook color tablet all on same network, yet the only computer that I have trouble watching YouTube or any other streaming media is on the wired PC. All the other devices are wireless, and they can watch streaming media, and YouTube without issues, what can be causing the wired computer this issue?

What are the specs of the wired PC?

If one of the other devices has a wired port, try using it wired and see if the problem persists trying to isolate the problem to the wired PC, cable, or the switch/router/other gadget that the other end of the cable is plugged into.

Check te wred computer for viruses and malware