I am putting in an addition in my home and drawing up plans for the permit. Can I run 14/2 wire from the panel to a switch and to 12 flood lights? I would run a wire from one light to the other.

Sure. It is rare to find cans/trims rated for 150 watts any more so even at 100 watts per can you are still fine with a 15A circuit.
Don't put anything else on the circuit though!