My 98 Accord with 250,000 miles will stop running while I an driving down the road. I can put it into neutral, restart the engind then shift back to drive. I never know when the engin will cut out. Does anyone have an idea on what might be causing this?

Read sections A and B in the link below:

https://www.askmehelpdesk.com/cars-trucks/faq-how-troubleshoot-repair-maintain-honda-civics-46563.html

Because of the mileage on the car, I would replace the Ignition Control Module (igniter) and coil inside the distributor. These are problematic components on Hondas. Also, make sure your spark plugs are in good shape.