First, are you trying to open a DVD-R disc, if so then it might that the content on the disc might have not been properly copied which may cause this problem.

Second, the lens of your DVD drive might be weak, which might cause this problem, because of weak lens it can't read the data of the disc properly.

Is either the lens of the DVD is weak or there is virus which is obstacle to the files to open ,so you better use antivirus to scan the p.c or you try another DVD rom.