2000 mercedes clk 430 I need to replace the drivers side front wheel spindle... I'm looking for any tips, how to's or the level of difficulty...

I'm unfamiliar with your car, but the link below may provide some guidance. Removing the caliper, caliper bracket, and disc should be very similar. The trick on some cars is being able to drop the subframe enough, in order to remove the lower ball joint from the lower control arm. Once you do that, you can easily remove the steering knuckle.

https://www.askmehelpdesk.com/cars-trucks/faq-how-troubleshoot-repair-maintain-hondas-selected-other-vehicles-46563-9.html#post1691894

CaptainRich may chime it with one of his awesome diagrams on your car.. . Stand by.