Not the best at computers, so thanks for your help. Lots of times when I'm on the internet, in the bottom right hand corner a box comes up from mcafee saying it doesn't recognize a change someone wants to make to my computer.

It says:
Internet explorer url's
Change: registry modified

c: program files
Internet explorer.exe

Affected items hkey_users\s-1-5-21 1081635173-2200288930-336076505-1007\software\microsoftint.explorer\main\window_pl acement.

Then it says the source is from Microsoft corporation. This pops up constantly. When I run a scan, items detected keep coming up ever since this. It always asks if I want to allow or block this change. I don't know what to do.

If mcafee says its from Microsoft, it may be a Windows update you need. I would allow.

It sounds like it's simply trying to memorize where you last put the IE window. Allow it.