My 4 year old multipoo has not eaten or drank water the last couple of days. All she does is sleep. What could be wrong with her?

You really need to get her to a vet asap.

Dogs can go around 5 days with no food but don't last long without water.

If you can't get her to the vet immediately get some pedialyte and syringe a small amount down her throat every 15 minutes to half hour to keep her hydrated until you can seek vet help.