After a freeze last winter my female sago grew a large ball in the center. It hasn't opened up. It just sits there and no new leaves are growing from it. What do I do? Should I remove the seed pod? The male grew a large cone from the center but it has since fallen off. Then it grew really fast.

Hi! bandedavis, welcome to AMHD :)

Don't remove it, that will only invite disease. Allow the Sago to purge it naturally.
An excellent site:
The Sago Palm, Cycas revoluta (http://www.junglemusic.net/cycadadvice/cycads-sago-palm2.htm)

Do you notice any yellowing of the Cycad? You could try 1 teaspoon of epson salts in a gallon of water.

K