I have a MIDI device that I just introduced to a 64-bit Vista system. It seems to interfere with my sound device and causes the recording software to fail catastrophically. Any ideas what I might pursue?

Any ideas what I might pursue?

A 32 bit Windows XP system... :D

Or, check with the MIDI device, sound card, and recording software manufacturer/vendor for Vista 64 bit driver/software updates and any known issues for this hardware combination on the Vista/64 platform.