The story takes place in 17th century England. A tailor who has the bubonic plague is sent to a small village outside of London. The village people get infected, the small village is quarantined they are not allowed to go outside their village or to receive outside visitors. The 2nd person to die after the tailor is the villate "witch doctor" whose name I believe is Agness. The heroine of the story is a widow whose husband dies in a mining accident. She is left with her two little boys who die of the plague. She has a romatic fling with the pastor and eventually moves to Italy pregnant with the pastor's child. If anyone is familiar with this book, please provide the titble. Many thanks.

Your description sounds like this one:

Year of Wonders: A Novel of the Plague
By Geraldine Brooks

Here's a link with plot summaries:

Powell's Books - Year of Wonders: A Novel of the Plague by Geraldine Brooks (http://www.powells.com/cgi-bin/biblio?isbn=9780142001431&atch=h&ymal=pp)