When I am opening my local computer drive it is showing open with option.
I scanned for virus and I didn't find any virus. And also no AUTORUN.INF file in the system.
Please any one can help me..?

This link should solve your issue.
Fix Open With issue on C drive. (http://wiki.answers.com/Q/When_you_double_click_your_c_drive_it_gives_you_an _option_to_choose_a_programme_to_open_withwhat_can _you_do_to_open_it_by_double_click)