I got a new puppy and she received her first set of shots today. She's home with me now, but she looks sick, could something be wrong?? She pooped a while ago and I cleaned it after that I dried it but a little blood came out her butt, is this normal??

GET HER TO THE VET NOW! Lethargy and bloody diarrhea are the classic symptoms of parvo. About once a week we see a post something like yours and a couple of days later the puppy is dead. You don't have all the symptoms yet, but if it is parvo, the sooner the puppy is on IV at the vet clinic, the more likely it is to live. This is Friday, you don't want to be paying weekend rates for a puppy suddenly fighting for its life. It is very easy for anybody giving advice to scream take the dog to the vet for every little thing. I don't do that with my own puppies, and try not to send others to the vet unnecessarily. This is a time to panic.