I would like to make a handbag. How can I print a graphic onto leather?

I'm not sure of the exact procedure nor the kind of graphic about which you are speaking. But, I do know that there are ways to do it based upon the things that I found on the following search.

printing on leather - Google Search (http://www.google.com/search?hl=en&safe=off&q=printing+on+leather)

Hopefully, someone will come along who has actually experienced doing what you are asking about though.