My sister asked me about a movie from the '80's where a group of guys go down into the Bayou to look for their friend and get lost and preyed upon by the Bayou people and only 2 guys come out alive.
Thank-you,
Sapphrina

Hi Sapphrina. It's not an exact match for the description, but the only movie that comes to mind is "Southern Comfort (1981)." Hope this helps.