My puppy was outside earlier today & she got stung by something on her padding of her back left foot. I put ice on it & I've been watching her. She keeps moving around and can't get comfortable she's also crying. Right now the vet's closed. & I don't know what to do?

Try some Benadryl, up to 2 mg per pound of body weight every 8 hours. I seldom suggest medicating your dog yourself, but this is one case I will until you can get to the vet in the morning. Be sure and tell the vet about the Benadryl so he correctly interrupts the symptoms correctly.