I have a Lenovo H535 desktop computer with Windows 8 64 Bit. The mouse is a wired mouse.
Using Chrome. This issue happens in both regular and incognito. When I try to push the scroll button on the mouse it does not close tabs or open links. The mouse I am using is the one that came with the PC. The only thing I am able to do with the scroll key is to scroll up and down pages. Fast/Quick scroll does not work or turn on/activate either. Could an extension cause this? I disabled all extensions but the issue was not resolved. Please tell me how to fix this issue.
Thanks for your help.

Chrome seems to have problems with the middle button from time to time. If you Google around you'll see numerous people complaining of the same thing.

You might try the middle click mini (https://chrome.google.com/webstore/detail/middle-click-mini/jnpgomjchhllpeehnmjfcfoceboliing) browser extension. This basically removes the ability of certain webpages to steal the middle-button events out from under you.

Good luck,
WallyH